A cost-effectiveness analysis of tactical satellites, high-altitude long-endurance airships, and high and medium altitude unmanned aerial systems for ISR and communication missions

Before 1991, the United States military's demand for additional communications bandwidth and timely intelligence was rising rapidly. Since then, with the advent of the Global War on Terrorism, it has increased substantially. To address this growing need, the Department of Defense has focused its acquisition and procurement efforts on obtaining new communications and intelligence, surveillance, and reconnaissance (ISR) platforms that can help lessen shortfalls and possibly exploit new, untapped resources. Recently, there has been an increasing focus on new technology, such as tactical satellites or high-altitude long-endurance airships, as a way to increase communications and intelligence collection capacities. Likewise, advances in the capabilities of medium-altitude and high-altitude unmanned aerial systems have resulted in a more prominent role for them on today's battlefield. Each of these vehicles has a unique niche in today's military, but the increasing capabilities of each are beginning to create some overlap in their uses. This study will conduct a cost-effectiveness analysis on these systems for use as a persistent communications and ISR platform. In particular, it will measure the effectiveness of each for comparison, and will offer possibilities to increase the overall effective use of the three together to maximize performance and cost.http://archive.org/details/acosteffectivene109453934US Army (USA) author.Approved for public release; distribution is unlimited

Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk

Background: The risk of sexual transmission of HIV-1 is strongly associated with the level of HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important target for HIV-1 prevention interventions. A quantitative understanding of the relationship of plasma HIV-1 RNA and HIV-1 transmission risk could help predict the impact of candidate HIV-1 prevention interventions that operate by reducing plasma HIV-1 levels, such as antiretroviral therapy (ART), therapeutic vaccines, and other non-ART interventions. Methodology/Principal Findings: We use prospective data collected from 2004 to 2008 in East and Southern African HIV-1 serodiscordant couples to model the relationship of plasma HIV-1 RNA levels and heterosexual transmission risk with confirmation of HIV-1 transmission events by HIV-1 sequencing. The model is based on follow-up of 3381 HIV-1 serodiscordant couples over 5017 person-years encompassing 108 genetically-linked HIV-1 transmission events. HIV-1 transmission risk was 2.27 per 100 person-years with a log-linear relationship to log10 plasma HIV-1 RNA. The model predicts that a decrease in average plasma HIV-1 RNA of 0.74 log10 copies/mL (95% CI 0.60 to 0.97) reduces heterosexual transmission risk by 50%, regardless of the average starting plasma HIV-1 level in the population and independent of other HIV-1-related population characteristics. In a simulated population with a similar plasma HIV-1 RNA distribution the model estimates that 90% of overall HIV-1 infections averted by a 0.74 copies/mL reduction in plasma HIV-1 RNA could be achieved by targeting this reduction to the 58% of the cohort with plasma HIV-1 levels ≥4 log10 copies/mL. Conclusions/Significance: This log-linear model of plasma HIV-1 levels and risk of sexual HIV-1 transmission may help estimate the impact on HIV-1 transmission and infections averted from candidate interventions that reduce plasma HIV-1 RNA levels

Friedrich Hayek and his visits to Chile

F. A. Hayek took two trips to Chile, the first in 1977, the second in 1981. The visits were controversial. On the first trip he met with General Augusto Pinochet, who had led a coup that overthrew Salvador Allende in 1973. During his 1981 visit, Hayek gave interviews that were published in the Chilean newspaper El Mercurio and in which he discussed authoritarian regimes and the problem of unlimited democracy. After each trip, he complained that the western press had painted an unfair picture of the economic situation under the Pinochet regime. Drawing on archival material, interviews, and past research, we provide a full account of this controversial episode in Hayek’s life

The spectral variability of the GHz-peaked spectrum radio source PKS 1718-649 and a comparison of absorption models

Using the new wideband capabilities of the ATCA, we obtain spectra for PKS 1718-649, a well-known gigahertzpeaked spectrum radio source. The observations, between approximately 1 and 10 GHz over 3 epochs spanning approximately 21 months, reveal variability both above the spectral peak at ~3 GHz and below the peak. The combination of the low- and high-frequency variability cannot be easily explained using a single absorption mechanism, such as free-free absorption or synchrotron self-absorption. We find that the PKS 1718-649 spectrum and its variability are best explained by variations in the free-free optical depth on our line of sight to the radio source at low frequencies (below the spectral peak) and the adiabatic expansion of the radio source itself at high frequencies (above the spectral peak). The optical depth variations are found to be plausible when X-ray continuum absorption variability seen in samples of active galactic nuclei is considered. We find that the cause of the peaked spectrum in PKS 1718-649 is most likely due to free-free absorption. In agreement with previous studies, we find that the spectrum at each epoch of observation is best fit by a free-free absorption model characterized by a power-law distribution of free-free absorbing clouds. This agreement is extended to frequencies below the 1 GHz lower limit of the ATCA by considering new observations with Parkes at 725 MHz and 199 MHz observations with the newly operational Murchison Widefield Array. These lower frequency observations argue against families of absorption models (both free-free and synchrotron self-absorption) that are based on simple homogenous structures

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead